Drug-induced liver disease /
Presents the latest discoveries in preventative therapy and surveillance of drug-induced liver injury. Emphasizes mechanisms, risk factors, clinical manifestations, pathology, and the management of various toxins
| Other Authors: | , |
|---|---|
| Format: | Book |
| Language: | English |
| Published: |
New York :
Marcel Dekker,
2003
New York : [2003], ©2003 New York : c2003 New York : 2003 |
| Subjects: |
Table of Contents:
- 1 Drug-Induced Liver Disorders: Introduction and Overview / Neil Kaplowitz
- 2. The Role of Cytochrome P450s in Drug-Induced Liver Disease / Paul B. Watkins
- 3. Oxidative Stress, Antioxidant Defense, and Liver Injury / Hartmut Jaeschke
- 4. Hepatotoxicity Due to Mitochondrial Injury / Dominique Pessayre, Abdellah Mansouri, Bernard Fromenty and Alain Berson
- 5. Mechanisms of Cell Death of Relevance to Drug Hepatotoxicity / Neil Kaplowitz
- 6. The Role of Membrane Transport in Drug-Induced Hepatotoxicity and Cholestasis / Peter L. M. Jansen and Michael Muller
- 7. Immunological Mechanisms in Liver Injury / Petra Obermayer-Straub and Michael Peter Manns
- 8. Mechanistic Role of Acyl Glucuronides / Chunze Li and Leslie Z. Benet
- 9. Nonparenchmal Cells, Inflammatory Macrophage, and Hepatotoxicity / Debra L. Laskin and Carol R. Gardner
- 1 Drug-Induced Liver Disorders: Introduction and Overview / Neil Kaplowitz
- 2. The Role of Cytochrome P450s in Drug-Induced Liver Disease / Paul B. Watkins
- 3. Oxidative Stress, Antioxidant Defense, and Liver Injury / Hartmut Jaeschke
- 4. Hepatotoxicity Due to Mitochondrial Injury / Dominique Pessayre, Abdellah Mansouri, Bernard Fromenty and Alain Berson
- 5. Mechanisms of Cell Death of Relevance to Drug Hepatotoxicity / Neil Kaplowitz
- 6. The Role of Membrane Transport in Drug-Induced Hepatotoxicity and Cholestasis / Peter L. M. Jansen and Michael Muller
- 7. Immunological Mechanisms in Liver Injury / Petra Obermayer-Straub and Michael Peter Manns
- 8. Mechanistic Role of Acyl Glucuronides / Chunze Li and Leslie Z. Benet
- 9. Nonparenchmal Cells, Inflammatory Macrophage, and Hepatotoxicity / Debra L. Laskin and Carol R. Gardner
- 10. Role of Cytokines and Growth Factors in Liver Regeneration, Repair, and Fibrosis After Liver Injury / Rebecca Taub, Meena Bansal and Wei Lei
- 11. Clinicopathological Patterns of Drug-Induced Liver Disease / Willis C. Maddrey
- 12. Histopathology of Drug-Induced Liver Disease / Gary C. Kanel
- 13. Mechanisms of Acetaminophen-Induced Liver Disease / Sidney D. Nelson and Sam A. Bruschi
- 14. Acetaminophen: Pathology and Clinical Presentation of Hepatotoxicity / William A. Lee and George Ostapowicz
- 15. Mechanisms Underlying the Hepatotoxicity of Nonsteroidal Anti-Inflammatory Drugs / Urs A. Boelsterli
- 16. Nonsteroidal Anti-Inflammatory Drugs: Pathology and Clinical Presentation of Hepatotoxicity / James H. Lewis
- 17. Mechanism, Pathology, and Clinical Presentation of Hepatotoxicity of Anesthetic Agents / J. Gerald Kenna
- 18. Anticonvulsant Agents / J. Steven Leeder and Munir Pirmohamed
- 19. Hepatotoxicity of Psychotropic Drugs and Drugs of Abuse / Kia Saeian and K. Rajender Reddy
- 20. Antibacterials and Antifungal Agents / Jean Frederic Westphal and Jean Marie Brogard
- 21. Antituberculous Agents-Induced Liver Injury / Pramod Kumar Garg and Rakesh Kumar Tandon
- 22. Hepatic Injury from Antiviral Agents / Maurizio Bonacini, Stan Louie and Kevin Weissman
- 23. Hepatotoxicity of Cardiovascular and Antidiabetic Drugs / Felix A. de la Iglesia, Jeffrey R. Haskins and George Feuer
- 24. Cancer Chemotherapy / Laurie D. DeLeve
- 25. Immunomodulating Agents and the Transplant Situation / Mary F. Hebert, Shari L. Taylor and Robert L. Carithers, Jr.
- 26. Methotrexate Controversies / Adrian Reuben
- 27. Adverse Effects of Hormones and Hormone Antagonists on the Liver / Muhammad Naeem and Steven Schenker
- 28. Alternative Medicine, Vitamins, and Natural Hepatotoxins / Georges-Philippe Pageaux and Dominique Larrey
- 29. Occupational and Environmental Hepatotoxicity / Keith G. Tolman
- 30. Regulatory Perspectives / John R. Senior.
- Part I Mechanisms
- 1 Drug-Induced Liver Disorders: Introduction and Overview / Neil Kaplowitz 1
- 2 The Role of Cytochrome P450s in Drug-Induced Liver Disease / Paul B. Watkins 15
- 3 Oxidative Stress, Antioxidant Defense, and Liver Injury / Hartmut Jaeschke 35
- 4 Hepatotoxicity Due to Mitochondrial Injury / Dominique Pessayre, Abdellah Mansouri, Bernard Fromenty, Alain Berson 55
- 5 Mechanisms of Cell Death and Relevance to Drug Hepatotoxicity / Neil Kaplowitz 85
- 6 The Role of Membrane Transport in Drug-Induced Hepatotoxicity and Cholestasis / Peter L. M. Jansen, Michael Muller 97
- 7 Immunological Mechanisms in Liver Injury / Petra Obermayer-Straub, Michael Peter Manns 125
- 8 Mechanistic Role of Acyl Glucuronides / Chunze Li, Leslie Z. Benet 151
- 9 Nonparenchymal Cells, Inflammatory Macrophages, and Hepatotoxicity / Debra L. Laskin, Carol R. Gardner 183
- 10 Roles of Cytokines and Growth Factors in Liver Regeneration, Repair, and Fibrosis After Liver Injury / Rebecca Taub, Meena Bansal, Wei Lei 213
- Part II Diagnosis and Management
- 11 Clinicopathological Patterns of Drug-Induced Liver Disease / Willis C. Maddrey 227
- 12 Histopathology of Drug-Induced Liver Disease / Gary C. Kanel 243
- Part III Hepatotoxicity of Specific Drugs
- 13 Mechanisms of Acetaminophen-Induced Liver Disease / Sidney D. Nelson, Sam A. Bruschi 287
- 14 Acetaminophen: Pathology and Clinical Presentation of Hepatotoxicity / William A. Lee, George Ostapowicz 327
- 15 Mechanisms Underlying the Hepatotoxicity of Nonsteroidal Anti-Inflammatory Drugs / Urs A. Boelsterli 345
- 16 Nonsteroidal Anti-Inflammatory Drugs: Pathology and Clinical Presentation of Hepatotoxicity / James H. Lewis 377
- 17 Mechanism, Pathology, and Clinical Presentation of Hepatotoxicity of Anesthetic Agents / J. Gerald Kenna 405
- 18 Anticonvulsant Agents / J. Steven Leeder, Munir Pirmohamed 425
- 19 Hepatotoxicity of Psychotropic Drugs and Drugs of Abuse / Kia Saeian, K. Rajender Reddy 447
- 20 Antibacterials and Antifungal Agents / Jean Frederic Westphal, Jean Marie Brogard 471
- 21 Antituberculous Agents-Induced Liver Injury / Pramod Kumar Garg, Rakesh Kumar Tandon 505
- 22 Hepatic Injury from Antiviral Agents / Maurizio Bonacini, Stan Louie, Kevin Weissman 519
- 23 Hepatotoxicity of Cardiovascular and Antidiabetic Drugs / Felix A. de la Iglesia, Jeffrey R. Haskins, George Feuer 549
- 24 Cancer Chemotherapy / Laurie D. DeLeve 593
- 25 Immunomodulating Agents and the Transplant Situation / Mary F. Hebert, Shari L. Taylor, Robert L. Carithers 633
- 26 Methotrexate Controversies / Adrian Reuben 653
- 27 Adverse Effects of Hormones and Hormone Antagonists on the Liver / Muhammad Naeem, Steven Schenker 677
- 28 Alternative Medicine, Vitamins, and Natural Hepatotoxins / Georges-Philippe Pageaux, Dominique Larrey 709
- 29 Occupational and Environmental Hepatotoxicity / Keith G. Tolman 725
- Part IV Regulatory Perspectives
- 10 Role of Cytokines and Growth Factors in Liver Regeneration, Repair, and Fibrosis After Liver Injury / Rebecca Taub, Meena Bansal and Wei Lei
- 11. Clinicopathological Patterns of Drug-Induced Liver Disease / Willis C. Maddrey
- 12. Histopathology of Drug-Induced Liver Disease / Gary C. Kanel
- 13. Mechanisms of Acetaminophen-Induced Liver Disease / Sidney D. Nelson and Sam A. Bruschi
- 14. Acetaminophen: Pathology and Clinical Presentation of Hepatotoxicity / William A. Lee and George Ostapowicz
- 15. Mechanisms Underlying the Hepatotoxicity of Nonsteroidal Anti-Inflammatory Drugs / Urs A. Boelsterli
- 16. Nonsteroidal Anti-Inflammatory Drugs: Pathology and Clinical Presentation of Hepatotoxicity / James H. Lewis
- 17. Mechanism, Pathology, and Clinical Presentation of Hepatotoxicity of Anesthetic Agents / J. Gerald Kenna
- 18. Anticonvulsant Agents / J. Steven Leeder and Munir Pirmohamed
- 19 Hepatotoxicity of Psychotropic Drugs and Drugs of Abuse / Kia Saeian and K. Rajender Reddy
- 20. Antibacterials and Antifungal Agents / Jean Frederic Westphal and Jean Marie Brogard
- 21. Antituberculous Agents-Induced Liver Injury / Pramod Kumar Garg and Rakesh Kumar Tandon
- 22. Hepatic Injury from Antiviral Agents / Maurizio Bonacini, Stan Louie and Kevin Weissman
- 23. Hepatotoxicity of Cardiovascular and Antidiabetic Drugs / Felix A. de la Iglesia, Jeffrey R. Haskins and George Feuer
- 24. Cancer Chemotherapy / Laurie D. DeLeve
- 25. Immunomodulating Agents and the Transplant Situation / Mary F. Hebert, Shari L. Taylor and Robert L. Carithers, Jr.
- 26. Methotrexate Controversies / Adrian Reuben
- 27. Adverse Effects of Hormones and Hormone Antagonists on the Liver / Muhammad Naeem and Steven Schenker
- 28. Alternative Medicine, Vitamins, and Natural Hepatotoxins / Georges-Philippe Pageaux and Dominique Larrey
- 29 Occupational and Environmental Hepatotoxicity / Keith G. Tolman
- 30. Regulatory Perspectives / John R. Senior.